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China, E-mail: ten. This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. The purpose of the present retrospective study was to investigate the significance of the BRAF-VE mutation in predicting prognostic and aggressive clinicopathological characteristics according to a new age-based stratification.

Aggressive clinicopathological factors associated with recurrence were analyzed by Cox multivariate regression. The synergistic interaction between BRAF-VE mutation and the new age stratification may help clinicians reach the optimal decision in terms of surgical approach and the extent of surgery. Keywords: papillary thyroid carcinoma, BRAF mutation, prognosis, recurrence Introduction Thyroid cancer is the most common endocrine malignancy, and its incidence has rapidly increased globally over the past few decades.

The incidence rate of thyroid cancer tripled from 4. This mutation is associated with aggressive tumor behavior, disease recurrence and disease-specific mortality in PTC 5 — 7. Based on these data, it appears that the BRAF-VE status in isolation is not sufficient to substantially contribute to risk stratification in the majority of the patients.

In addition, an incremental improvement in risk stratification may be achieved if the BRAF-VE mutational status is considered in the context of other standard clinicopathological risk factors The aim of the present study was to investigate whether the synergistic interaction between BRAF-VE mutational status and the new age stratification with a cut-off age of 55 years is more efficient in predicting the prognosis of PTC.

A comprehensive multi-dimensional map of the key genomic changes in 33 types of cancer has been generated.

High-quality tumor and matched normal samples from patients with thyroid cancer were collected and identified via the TCGA database, of which patients had complete clinicopathological data. A total of patients diagnosed with PTC, including women The median age of the patients was 46 years [interquartile range IQR , 35—58 years].

Table I.


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